Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

3.7K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
3.7K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.9K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

4.8K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

8.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.3K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

2.6K
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Piroctone olamine promotes BECN1 transcription and activates autophagy by targeting HDAC6 in colorectal cancer.

Acta pharmacologica Sinica·2026
Same author

The role of HMGA1 in genome stability: Implications in human cancer.

Cellular and molecular life sciences : CMLS·2026
Same author

Prefrontal cortex-to-hypothalamic outputs orchestrate cue-potentiated palatable food consumption via AMPKβ2 signaling.

Cell discovery·2026
Same author

Association between weekly sleep duration and gallstones in a US-based adult sample: A cross-sectional study.

Medicine·2025
Same author

Activation of TLR4-NF-κB signaling in renal tubular epithelial cells facilitates renal allograft fibrosis by inhibiting peroxisome biogenesis.

Biochimica et biophysica acta. Molecular basis of disease·2025
Same author

An excitatory circuit in the ventrolateral periaqueductal gray drives hypometabolic state during acute systemic inflammation.

Cell reports·2025

Related Experiment Video

Updated: May 4, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

19.0K

Targeting the LKB1 tumor suppressor.

Rui-Xun Zhao, Zhi-Xiang Xu1

  • 1Division of Hematology and Oncology, Comprehensive Cancer Center, University of Alabama at Birmingham, 1824 6th Avenue South, Wallace Tumor Institute Building, Room 520D, Birmingham, AL 35294, USA. zhixiangxu@uabmc.edu.

Current Drug Targets
|January 7, 2014
PubMed
Summary

Serine-threonine kinase 11 (LKB1) is a tumor suppressor involved in cell functions and cancer. This review discusses agents targeting aberrant LKB1 signaling for personalized cancer therapy.

More Related Videos

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
14:34

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English

Published on: April 3, 2026

300
Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

1.5K

Related Experiment Videos

Last Updated: May 4, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

19.0K
A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
14:34

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English

Published on: April 3, 2026

300
Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

1.5K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • LKB1 (serine-threonine kinase 11) is a crucial tumor suppressor gene.
  • Mutations in LKB1 are linked to Peutz-Jeghers syndrome and various cancers.
  • LKB1 regulates fundamental cellular processes including metabolism, cell cycle, polarity, and apoptosis.

Purpose of the Study:

  • To review the role of LKB1 in cancer and its physiological functions.
  • To discuss current therapeutic strategies targeting aberrant LKB1 signaling.
  • To explore potential agents and challenges in LKB1-targeted cancer therapy.

Main Methods:

  • Literature review of studies on LKB1 function and therapeutic targeting.
  • Analysis of agents with activity against LKB1 signaling pathways.
  • Discussion of challenges and future directions in LKB1-targeted therapy.

Main Results:

  • LKB1 plays a significant role in tumor suppression and cellular homeostasis.
  • Aberrant LKB1 signaling is implicated in the development and progression of diverse cancers.
  • Several therapeutic agents show potential for targeting LKB1-driven cancers.

Conclusions:

  • Targeting LKB1 inactivation represents a promising avenue for personalized cancer medicine.
  • Further research is needed to overcome challenges in developing effective LKB1-targeted therapies.
  • Understanding LKB1's multifaceted roles is key to advancing cancer treatment strategies.