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Interferons and their clinical value.

D A Tyrrell

    Reviews of Infectious Diseases
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Interferons, discovered for antiviral effects, are proteins with diverse immune functions. Research shows alpha interferons are effective in preventing and treating viral infections.

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    Area of Science:

    • Immunology
    • Virology
    • Molecular Biology

    Background:

    • Interferons (IFNs) are proteins initially recognized for their antiviral properties.
    • They are produced by various vertebrate species and modulate cellular responses, including immune reactions and cell division.
    • IFNs are induced by viral or double-stranded RNA exposure, with gamma interferon being a lymphokine.

    Purpose of the Study:

    • To review the discovery and diverse functions of interferons.
    • To highlight the molecular basis and genetic aspects of interferons.
    • To discuss the therapeutic applications of interferons, particularly alpha interferon.

    Main Methods:

    • Review of existing literature on interferon discovery and function.
    • Analysis of genetic sequencing and expression data for human interferons.

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  • Examination of clinical data regarding parenteral administration of interferons.

    • Main Results:

    • Interferons exhibit a broad range of effects, including antiviral states and immune modulation.
    • Genes for human alpha, beta, and gamma interferons have been successfully cloned and sequenced.
    • Parenteral administration of interferons can induce flu-like symptoms.
    • Natural and recombinant alpha interferons demonstrate efficacy in managing viral infections.

    Conclusions:

    • Interferons are crucial components of the innate immune system with diverse biological activities.
    • The genetic understanding and therapeutic potential of interferons, especially alpha interferon, are significant.
    • Interferons play a role in both natural host defense against viruses and as therapeutic agents.