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Updated: May 4, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Parameter estimation and optimal scheduling algorithm for a mathematical model of intermittent androgen suppression
Qian Guo1, Zhichang Lu1, Yoshito Hirata2
1Department of Mathematics, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, China.
Abstract:
We propose an algorithm based on cross-entropy to determine parameters of a piecewise linear model, which describes intermittent androgen suppression therapy for prostate cancer. By comparing with clinical data, the parameter estimation for the switched system shows good fitting accuracy and efficiency. We further optimize switching time points for the piecewise linear model to obtain a feasible therapeutic schedule. The simulation results of therapeutic effect are superior to those of previous strategy.
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