Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rehospitalization Burden Profiles After Traumatic Spinal Cord Injury: A Data-Driven Latent Class Analysis of the SCIMS Public-Use Database.

Journal of clinical medicine·2026
Same author

Neurogenic Pelvic Floor Dysfunctions Across Neurological Disorders: Mechanisms, Phenotypes, and Precision Rehabilitation Pathways-A Narrative Review.

Journal of clinical medicine·2026
Same author

Muscle and mind: rewiring cognitive-motor recovery through exercise-responsive neurophysiology in neurological populations.

Frontiers in psychology·2026
Same author

Multimodal rehabilitation in PLP1-associated spastic paraparesis: a case report with clinical and biomechanical outcomes.

Frontiers in rehabilitation sciences·2026
Same author

Safety Profile of Zavegepant in the Treatment of Acute Migraine: Insights from the FDA Adverse Event Monitoring System Database.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

High-density EEG network analysis in MCI: an exploratory study of electrode density and cognitive performance.

Frontiers in aging neuroscience·2026

Related Experiment Video

Updated: May 4, 2026

Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation
10:11

Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation

Published on: January 3, 2020

13.3K

Increased transcranial direct current stimulation after effects during concurrent peripheral electrical nerve

Vincenzo Rizzo1, Carmen Terranova1, Domenica Crupi2

  • 1Department of Neurosciences, Psychiatry and Anaesthesiology, University of Messina, Italy.

Brain Stimulation
|January 7, 2014
PubMed
Summary

Combining peripheral nerve stimulation with transcranial direct current stimulation (tDCS) effectively induces lasting changes in human motor cortex excitability. This neurostimulation approach offers a novel method for bidirectional plasticity, impacting both motor evoked potentials and H-reflexes.

Keywords:
Motor cortexPeripheral electrical current stimulationPlasticityTranscranial direct current stimulationTranscranial magnetic stimulation

More Related Videos

Simultaneous EEG Monitoring During Transcranial Direct Current Stimulation
07:52

Simultaneous EEG Monitoring During Transcranial Direct Current Stimulation

Published on: June 17, 2013

41.6K
Electrode Positioning and Montage in Transcranial Direct Current Stimulation
12:00

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Published on: May 23, 2011

268.8K

Related Experiment Videos

Last Updated: May 4, 2026

Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation
10:11

Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation

Published on: January 3, 2020

13.3K
Simultaneous EEG Monitoring During Transcranial Direct Current Stimulation
07:52

Simultaneous EEG Monitoring During Transcranial Direct Current Stimulation

Published on: June 17, 2013

41.6K
Electrode Positioning and Montage in Transcranial Direct Current Stimulation
12:00

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Published on: May 23, 2011

268.8K

Area of Science:

  • Neuroscience
  • Human Physiology
  • Motor Control

Background:

  • Cortical excitability changes are crucial for motor learning and rehabilitation.
  • Both repetitive peripheral nerve stimulation (rEPNS) and transcranial direct current stimulation (tDCS) can individually alter cortical excitability.
  • Investigating combined stimulation protocols may reveal synergistic effects on neuroplasticity.

Purpose of the Study:

  • To test if combining rEPNS with tDCS can induce lasting changes in human cortical output circuit excitability.
  • To determine if concurrent depolarization or hyperpolarization of the motor cortex via tDCS enhances neuroplasticity induced by rEPNS.
  • To explore the potential for bidirectional plasticity through combined neurostimulation.

Main Methods:

  • Ten healthy young volunteers participated in five stimulation protocols.
  • Protocols included anodal tDCS, cathodal tDCS, sham tDCS with rEPNS, and anodal/cathodal tDCS with rEPNS.
  • Motor evoked potentials (MEPs) and H-reflexes were measured immediately and up to 60 minutes post-stimulation.

Main Results:

  • Anodal tDCS alone caused transient MEP increases; combined with rEPNS, effects lasted 60 minutes.
  • Cathodal tDCS alone reduced MEPs; combined with rEPNS, effects also persisted for 60 minutes.
  • Both combined tDCS (anodal/cathodal) + rEPNS and sham tDCS + rEPNS induced lasting H-reflex facilitation.

Conclusions:

  • Combining afferent input (rEPNS) with modulated motor cortex excitability (tDCS) is effective for inducing enduring, bidirectional neuroplasticity.
  • This combined stimulation approach offers a powerful tool for modulating corticospinal excitability.
  • Potential mechanisms involve complex interactions, including cortical and spinal after-effects.