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Related Experiment Video

Updated: May 4, 2026

Pre-clinical Model of Cardiac Donation after Circulatory Death
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Pre-clinical Model of Cardiac Donation after Circulatory Death

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How France launched its donation after cardiac death program.

C Antoine1, F Mourey2, E Prada-Bordenave3

  • 1Agence de la biomédecine, direction générale médicale et scientifique, direction prélèvement greffe organes-tissus, pôle stratégie prélèvement greffe, 1, avenue du Stade-de-France, 93212 Saint-Denis-la-Plaine cedex, France.

Annales Francaises D'Anesthesie Et De Reanimation
|January 7, 2014
PubMed
Summary
This summary is machine-generated.

Donation after circulatory death (DCD) offers a valuable source of transplant organs. Implementing controlled DCD requires standardized protocols, ethical considerations, and specific medical criteria for successful organ retrieval and transplantation.

Keywords:
Cardiac death donorCirculatory deathDon d’organesDonneur décédé après arrêt cardiaqueDonor selectionDécès par arrêt circulatoireLimitation des thérapeutiques activesOrgan donationSélection du donneurWithdrawal of life-sustaining therapy

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Area of Science:

  • Transplantation Medicine
  • Bioethics
  • Intensive Care

Background:

  • Donation after circulatory death (DCD) is a significant source of high-quality transplantable organs.
  • Controlled DCD, primarily Maastricht category III donors, is the focus for increasing organ availability.
  • Previous recommendations emphasized the need for standardized procedures and ethical frameworks for DCD in France.

Purpose of the Study:

  • To outline the feasibility and necessary framework for implementing controlled donation after circulatory death in France.
  • To define medical, ethical, and procedural criteria for successful DCD programs.
  • To enhance national guidance for DCD to improve graft survival and acceptance.

Main Methods:

  • Review of literature and findings from the 6th International Conference on DCD.
  • Analysis of recommendations from Intensive Care Societies and ethics committees regarding controlled DCD.
  • Proposal for a standardized national protocol for determining death, procurement, and transplantation in pilot centers.

Main Results:

  • Controlled DCD is deemed possible and practical, providing a significant source of organs.
  • Key recommendations include: independent withdrawal of life-sustaining treatment (WLST) decisions, adherence to the 'dead donor rule', and a national protocol.
  • Organ donation after WLST should be authorized in specialized pilot centers with specific expertise and oversight.

Conclusions:

  • Standardized national guidance is crucial for DCD to mitigate risks of graft failure (e.g., ischemia time).
  • Implementation requires strict adherence to ethical principles and defined medical criteria.
  • Optimized DCD protocols will improve outcomes, increase medical and public acceptance, and enable robust data analysis.