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Correction for Brown-Elliott et al., "Utility of Sequencing the <i>erm</i>(41) Gene in Isolates of <i>Mycobacterium abscessus</i> subsp. <i>abscessus</i> with Low and Intermediate Clarithromycin MICs".

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Erratum for Brown-Elliott et al., Utility of Sequencing the erm(41) Gene in Isolates of Mycobacterium abscessus subsp. abscessus with Low and Intermediate Clarithromycin MICs.

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Utility of sequencing the erm(41) gene in isolates of Mycobacterium abscessus subsp. abscessus with low and intermediate clarithromycin MICs.

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Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes
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Recent progress towards understanding genetic variation in the Mycobacterium abscessus complex.

Susan T Howard1

  • 1Department of Microbiology, University of Texas Health Science Center at Tyler, Tyler, TX, 75708, USA.

Tuberculosis (Edinburgh, Scotland)
|January 7, 2014
PubMed
Summary

Mycobacterium abscessus infections are increasing. Genetic variation studies, using whole genome sequencing, are improving our understanding of disease, antibiotic resistance, and treatment strategies for this emerging pathogen.

Keywords:
GenomicsInfection modelsMycobacterium abscessusStrain typingSubspeciesVariants

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Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Mycobacterium abscessus is an emerging pathogen causing significant respiratory and soft tissue infections.
  • Understanding its genetic diversity is crucial for effective disease management.

Purpose of the Study:

  • To review recent advancements in understanding Mycobacterium abscessus genetic variation.
  • To explore the implications of this variation for disease pathogenesis and treatment.

Main Methods:

  • Whole genome sequencing
  • Molecular approaches
  • Infection models

Main Results:

  • Genomic studies are elucidating outbreak patterns, antibiotic resistance mechanisms, and virulence factors.
  • Infection models highlight the role of colony phenotype in host-pathogen interactions.

Conclusions:

  • Recent genetic insights offer new perspectives on Mycobacterium abscessus infections.
  • Understanding genetic variation is key to developing improved therapeutic strategies.