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Novel PARP-1 inhibitors based on a 2-propanoyl-3H-quinazolin-4-one scaffold

Giuseppe Giannini1, Gianfranco Battistuzzi1, Loredana Vesci1

  • 1R&D Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Via Pontina Km 30,400, I-00040 Pomezia (RM), Italy.

Bioorganic & Medicinal Chemistry Letters
|January 7, 2014
PubMed

Keywords:
3-(4-Oxo-3,4-dihydro-quinazolin-2-yl)-propionamidesAnticancerHit-to-lead optimizationMolecular modelingPARP-1 inhibitorsVirtual screening of commercial libraries

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