One-day versus two-day cleansing for colon capsule endoscopy: a prospective randomized pilot study

Area of Science:

• Gastroenterology
• Medical Devices
• Clinical Trials

Background:

• Standard bowel preparation for colon capsule endoscopy (CCE) involves a restrictive diet and laxatives for two days.
• This lengthy preparation is a significant barrier, negatively impacting patient tolerance and adherence.

Purpose of the Study:

• To evaluate the efficacy of a one-day bowel preparation regimen compared to a two-day regimen for CCE.
• To determine if a shortened preparation impacts colon cleanliness quality.

Main Methods:

• A randomized controlled trial comparing a one-day (fiber-free diet, 3L PEG) versus a two-day (liquid diet, 3L PEG day -1, 1L PEG day 0) bowel preparation.
• Both groups received bisacodyl and sodium phosphate boosters.
• Colon cleanliness was graded on a four-point scale, categorized as adequate (excellent/good) or inadequate (fair/poor).

Main Results:

• Overall adequate colon cleanliness was achieved in 94% of the one-day group versus 80% in the two-day group (P=0.27).
• No significant differences in per-segment cleanliness were found between the groups.
• CCE reached the rectum in 80% of the one-day group and 75% of the two-day group (p=0.59).

Conclusions:

• One-day bowel preparation is an effective alternative to the standard two-day regimen for CCE.
• This shortened preparation achieves equivalent colon cleanliness quality, enhancing patient experience.