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Lung function in wheezing infants

Manuel Sanchez-Solis1, Luis Garcia-Marcos1

  • 1Hospital Universitario Virgen de la Arrixaca. Pabellon Docente, Universitario. Campus Ciencias de la Salud, Ctra. Madrid-Cartagena, s/n. 30120 El Palmar, Murcia. Spain.

Frontiers in Bioscience (Elite Edition)
|January 7, 2014
PubMed

Insights

Recurrent wheeze in infants can persist into adulthood. Early infant lung function impairment is linked to persistent wheezing and later asthma, with specific risk factors identified.

Area of Science:

  • Pediatric respiratory medicine
  • Pulmonology
  • Epidemiology

Background:

  • Recurrent wheeze is common in infants, often transient but sometimes persistent.
  • Persistent recurrent wheeze can continue into adulthood, impacting long-term health.
  • Understanding risk factors and early lung function is crucial for managing persistent wheeze.

Purpose of the Study:

  • To review the relationship between recurrent wheeze and lung function impairment in infants.
  • To explore the early onset of lung function deficits associated with wheezing.
  • To examine the link between infant wheeze, lung function, and later-life asthma.

Main Methods:

  • Literature review of international cohort studies.
  • Analysis of existing data on infant lung function and wheezing phenotypes.
  • Synthesis of research on risk factors for persistent wheeze and low lung function.

Main Results:

  • Infant lung function plays a role in the pathophysiology of recurrent wheeze.
  • Impaired lung function can be detected early in life in infants with recurrent wheeze.
  • Certain risk factors are associated with reduced lung function in infancy.

Conclusions:

  • Early detection of lung function impairment in infants with recurrent wheeze is important.
  • Persistent recurrent wheeze and associated lung function deficits may predict later asthma.
  • Identifying risk factors for low infant lung function can inform preventative strategies.

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