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Published on: January 12, 2024
Atopic eczema: a disease modulated by gene and environment
Weian Mao1, Jingyi Mao2, Jian Zhang3
1Department of Dermatology, Shanghai Seventh People's Hospital, Shanghai, China;
Abstract:
Atopic eczema (AE) is a chronic inflammatory skin disease that is mainly characterized by pruritus and epidermal barrier dysfunction. Between 15% and 20% of children and 1%-3% of adults are affected worldwide. AE is a complex disease triggered by multiple triggers, including gene and environmental factors. Impaired skin barrier function, modifications of the immune system, and hyper-reactivity to environmental stimulation directly cause and aggravate AE. In this review, we provide an overview of the recent developments and future directions in the pathogenesis of AE.
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