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The association between BRAF (V600E) mutation and pathological features in PTC.
Xin Liu1, Kangkang Yan, Xuejun Lin
1Epidemiology and Statistics, School of Public Health, Jilin University, Changchun, Jilin, China.
The BRAF (V600E) mutation is linked to aggressive features in papillary thyroid carcinoma (PTC). This meta-analysis confirms its association with extra-thyroidal extension, advanced stage, lymph node metastasis, multifocality, and recurrence in PTC patients.
Area of Science:
- Oncology
- Genetics
- Pathology
Background:
- The BRAF (V600E) mutation is a frequent genetic alteration in papillary thyroid carcinoma (PTC).
- Previous studies on the association between BRAF (V600E) and PTC pathological features yielded inconclusive results.
Purpose of the Study:
- To conduct a meta-analysis exploring the association between the BRAF (V600E) mutation and pathological features in papillary thyroid carcinoma.
- To clarify the clinical significance of BRAF (V600E) in PTC.
Main Methods:
- A systematic literature search was performed using Medline, PubMed, and Web of Science.
- Data from 69 studies comprising 14,170 PTC patients (2004-2013) were analyzed using STATA12.0.
- Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess associations.
Main Results:
- The BRAF (V600E) mutation was significantly associated with extra-thyroidal extension (OR = 2.09).
- Associations were also found with advanced TNM stage (OR = 1.90), lymph node metastasis (OR = 1.68), multifocality (OR = 1.22), and recurrence (OR = 2.50).
Conclusions:
- The BRAF (V600E) mutation plays a role in the pathological features of papillary thyroid carcinoma.
- BRAF (V600E) status may offer valuable prognostic and diagnostic information for PTC patients.
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