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[Association between mesenteric phlebosclerosis and Chinese herbal medicine intake]
Kensei Ohtsu1, Toshiyuki Matsui, Taku Nishimura
1Department of Gastroenterology, Fukuoka University Chikushi Hospital.
Summary
Mesenteric phlebosclerosis (MP) is linked to Chinese herbal medicine. Continued use, especially of sanshishi, may worsen MP symptoms and contribute to its development.
Area of Science:
- Gastroenterology
- Pharmacology
- Pathology
Context:
- Mesenteric phlebosclerosis (MP) is a rare colonic disease.
- Recent studies suggest a link between MP and Chinese herbal medicine (CHM) intake.
Purpose:
- To investigate the association between MP and CHM intake.
- To analyze specific CHMs potentially linked to MP.
Summary:
- A study of 42 MP patients revealed a strong correlation with CHM use.
- Approximately 90% of treated patients reported CHM intake, with kamishoyosan, orengedokuto, and sanshishi (gardeniae fructus) being common.
- Sanshishi, particularly in crude form, was frequently consumed.
- MP symptom exacerbation was observed in patients continuing CHM use post-onset.
- A case of MP developing in a couple consuming the same CHM suggests a potential environmental or shared exposure factor.
Impact:
- Findings suggest a significant association between CHM intake, especially sanshishi, and MP development.
- Highlights the need for further research into the specific mechanisms and causative agents within CHM.
- Informs clinical practice regarding patient history and potential therapeutic interventions for MP.
