Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.4K
1.4K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Cancer Therapies02:49

Cancer Therapies

8.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Negative regulation of human IL-33 in endothelium during allergic airway inflammation.

JCI insight·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Immunity meets inhibition: Immunomodulation of cortical inhibitory synaptic networks.

Current opinion in neurobiology·2025
Same author

Benthic diel oxygen variability and stress as potential drivers for animal diversification in the Neoproterozoic-Palaeozoic.

Nature communications·2025
Same author

Correction to: Urinary extracellular vesicle‑derived miR‑126‑3p predicts lymph node invasion in patients with high‑risk prostate cancer.

Medical oncology (Northwood, London, England)·2025
Same author

Single-Cell Proteomic Characterization of Drug-Resistant Prostate Cancer Cells Reveals Molecular Signatures Associated with Morphological Changes.

Molecular & cellular proteomics : MCP·2025

Related Experiment Video

Updated: May 4, 2026

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
12:23

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

Published on: August 14, 2012

14.0K

A multi-targeted approach to treating bone metastases.

Daniel F Camacho1, Kenneth J Pienta

  • 1Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, 7431 CCC 1500 E Medical Ctr, Ann Arbor, MI, 48109, USA.

Cancer Metastasis Reviews
|January 7, 2014
PubMed
Summary

Treating bone metastasis involves targeting cancer cell interactions within the bone microenvironment. A "scaled network disruption" approach is key for successful outcomes in bone cancer treatment.

More Related Videos

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
07:00

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

16.4K
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

13.9K

Related Experiment Videos

Last Updated: May 4, 2026

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
12:23

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

Published on: August 14, 2012

14.0K
Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
07:00

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

16.4K
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

13.9K

Area of Science:

  • Oncology
  • Bone Biology
  • Cancer Therapeutics

Background:

  • Bone metastasis presents unique biological challenges and therapeutic opportunities.
  • The bone microenvironment comprises various cells and matrix components that interact with cancer cells.
  • Understanding these interactions is crucial for developing effective treatments.

Purpose of the Study:

  • To review the therapeutic targets arising from the interplay between cancer cells and the bone microenvironment.
  • To discuss ongoing efforts in understanding drug resistance mechanisms in bone metastasis.
  • To propose a comprehensive strategy for treating bone-metastatic cancer.

Main Methods:

  • Review of current literature on bone metastasis and therapeutic targets.
  • Analysis of cellular and molecular interactions within the bone microenvironment.
  • Synthesis of information on drug resistance mechanisms and co-targeting strategies.

Main Results:

  • Identified numerous therapeutic targets, including cancer cell interactions with osteoclasts, osteoblasts, endothelial cells, stromal cells, hematopoietic progenitor cells, immune cells, and the bone matrix.
  • Highlighted ongoing research into specific drug resistance mechanisms in the bone.
  • Emphasized the need for a multi-faceted approach to treatment.

Conclusions:

  • Effective treatment of bone metastasis requires co-targeting multiple tumor-supportive elements and pathways.
  • A "scaled network disruption" strategy, targeting tumor cells, microenvironments, and systemic effects, is proposed.
  • This comprehensive approach aims to undermine the disease state for improved clinical outcomes.