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Updated: May 4, 2026
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
Transformation of a primitive myxoid mesenchymal tumor of infancy to an undifferentiated sarcoma: a first reported
Marie-Christine Guilbert1, Anne-Laure Rougemont, Yvan Samson
1Departments of *Pathology ∥Surgery, CHU Sainte-Justine §Department of Pediatrics, Division of Hematology-Oncology, CHU Ste-Justine †Department of Pathology and Cellular Biology, Université de Montréal ¶Department of Surgery, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada ‡Division of Clinical Pathology, Hôpitaux Universitaires de Genève, Switzerland.
Abstract:
An 8-month-old girl underwent surgical resection of a cervical mass with histologic diagnosis of a primitive myxoid mesenchymal tumor of infancy (PMMTI). More than 5 years after the initial surgical intervention, the tumor recurred locally, with numerous distant metastases. The histologic morphology of this tumor was compatible with a diagnosis of an undifferentiated high-grade sarcoma. PMMTI is a recently described poorly differentiated fibroblastic soft-tissue tumor of infancy, of at least borderline biological behavior, characterized by local recurrence and a potential to metastasize. We present here the first case of a transformation of a PMMTI into an undifferentiated high-grade sarcoma.
