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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Drug Dosing: Geriatric Patients01:15

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Updated: May 4, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Urban American Indian aging.

B J Kramer1

  • 1Department of Community and Senior Citizens Services, County of Los Angeles, 1102 Crenshaw Boulevard, 90019-3198, Los Angeles, CA, U.S.A..

Journal of Cross-Cultural Gerontology
|January 7, 2014
PubMed
Summary
This summary is machine-generated.

Most urban American Indian elders wish to age in place. This study assesses their needs and the under-utilization of Older Americans Act services, recommending ways to improve access for this underserved population.

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Area of Science:

  • Gerontology
  • Sociology
  • Public Health

Background:

  • The majority of American Indians reside in urban areas, not reservations.
  • Urban American Indian elders are a growing demographic aging in place.
  • Little research has focused on the specific needs of urban American Indian elderly.

Purpose of the Study:

  • To assess the needs of urban American Indian elders.
  • To document the under-utilization of Older Americans Act services by this population.
  • To identify barriers to service access and recommend solutions.

Main Methods:

  • Needs assessment of urban American Indian elders.
  • Documentation of service utilization patterns.
  • Analysis of barriers to accessing Older Americans Act services.

Main Results:

  • Significant under-utilization of available services was identified.
  • Key barriers to access for urban American Indian elders were documented.
  • Specific recommendations for increasing participation were developed.

Conclusions:

  • Urban American Indian elders have distinct needs that are not being fully met.
  • Targeted interventions are required to improve access to services for urban American Indian elders.
  • Policy and program adjustments can enhance the well-being of this aging population.