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Updated: May 4, 2026
06:39
Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
Published on: October 3, 2018
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Large vessel vasculitis with myelodysplastic syndrome
Takayuki Katsuyama1, Haruhito Adam Uchida, Kishio Toma
1Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Internal Medicine (Tokyo, Japan)
|January 7, 2014
Summary
This case report details a rare instance of large vessel vasculitis occurring alongside myelodysplastic syndrome (MDS). The simultaneous diagnosis led to poor outcomes, highlighting a potential link between these conditions.
Area of Science:
- Hematology
- Rheumatology
- Oncology
Background:
- Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders.
- Immune-mediated disorders are known to occur in patients with MDS.
- Large vessel vasculitis is a rare but serious condition affecting major arteries.
Observation:
- A 71-year-old woman presented with fever, neck pain, anemia, and thrombocytopenia.
- Simultaneous diagnosis of large vessel vasculitis and myelodysplastic syndrome (MDS) was established.
- Initial treatment with glucocorticoids provided symptomatic relief.
Findings:
- The patient's myelodysplastic syndrome (MDS) transformed into acute myeloid leukemia.
- The patient died one year after the initial diagnosis.
- This case highlights the rare association between systemic vasculitis and MDS.
Implications:
- The co-occurrence of large vessel vasculitis and MDS may indicate a poor prognosis.
- Further research is warranted to understand the pathophysiology and management of this rare association.
- Clinicians should consider vasculitis in MDS patients presenting with relevant symptoms.
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