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Updated: May 4, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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Fetal immune response to chorioamnionitis.

Suhas G Kallapur1, Pietro Presicce1, Cesar M Rueda2

  • 1Division of Neonatology/Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati.

Seminars in Reproductive Medicine
|January 7, 2014
PubMed
Summary

Chorioamnionitis, an infection during pregnancy, often leads to preterm birth and fetal organ injury. This review examines animal models to understand immune responses and injury mechanisms in developing fetuses.

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Area of Science:

  • Obstetrics and Gynecology
  • Neonatology
  • Immunology

Background:

  • Chorioamnionitis is a common cause of preterm birth.
  • It involves low-virulence microbes in amniotic fluid, often without typical maternal infection symptoms.
  • This condition increases the risk of injury in fetal organs like the lungs, brain, and gastrointestinal tract.

Purpose of the Study:

  • To review the effects of chorioamnionitis in experimental animal models.
  • To analyze immune system changes in fetal organs due to chorioamnionitis.
  • To explore the pathogenesis of chorioamnionitis-induced fetal injury.

Main Methods:

  • Review of experimental animal models that mimic human chorioamnionitis.
  • Focus on immune responses across multiple fetal organs.
  • Examination of injury mechanisms in various fetal compartments.

Main Results:

  • Animal models demonstrate chorioamnionitis-induced immune alterations in fetal organs.
  • The pathogenesis of injury involves complex interactions within fetal compartments.
  • Preterm infants are disproportionately affected, highlighting developmental immune context.

Conclusions:

  • Chorioamnionitis poses significant risks to fetal development and organ health.
  • Understanding immune responses in animal models is crucial for mitigating preterm birth complications.
  • Further research is needed to translate findings into clinical strategies for affected infants.