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Cell disaggregation behavior in shear flow.

P Snabre, M Bitbol, P Mills

    Biophysical Journal
    |May 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Shear stress and cell adhesiveness, not cell volume or deformability, drive erythrocyte disaggregation in dextran solutions. Flow patterns influence critical shear stress for cell dispersion.

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    Area of Science:

    • Biophysics
    • Fluid Mechanics
    • Biomaterials

    Background:

    • Erythrocyte aggregation, forming rouleaux, impacts blood flow properties.
    • Understanding disaggregation is crucial for hemorheology and disease states.

    Purpose of the Study:

    • To investigate erythrocyte disaggregation in dextran solutions under various flow conditions.
    • To identify key factors influencing rouleau break-up and cell dispersion.
    • To develop a theoretical model for shear-induced erythrocyte disaggregation.

    Main Methods:

    • Utilized light reflectometry in Couette and plane Poiseuille flow.
    • Investigated effects of dextran concentration, molecular weight, cell volume fraction, and membrane deformability.
    • Analyzed critical shear rates and stresses for cell dispersion.

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    Main Results:

    • Dextran concentration and molecular weight significantly affect erythrocyte suspension reflectivity and dispersion.
    • Intercellular adhesiveness and shear stress are the primary drivers of rouleau break-up.
    • Cell volume fraction and membrane deformability do not influence rouleau break-up in steady shear flow.
    • Flow patterns (Couette vs. Poiseuille) affect critical shear stress for dispersion due to cell rotation and shear field non-uniformity.

    Conclusions:

    • Rouleau disaggregation is primarily governed by shear stress and inter-erythrocyte adhesion.
    • Flow hydrodynamics play a role in the critical shear stress required for dispersion.
    • This study provides a method to quantify shear forces for cell dispersion, enabling estimation of membrane adhesive energy.