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Ocular side effects of biological agents in oncology: what should the clinician be aware of?

Tobias Hager1, B Seitz1

  • 1Department of Ophthalmology, Universitätsklinikum des Saarlandes, Homburg, Germany.

Oncotargets and Therapy
|January 7, 2014
PubMed

Insights

Biological therapies for cancer have distinct ocular side effect profiles. This review categorizes biologicals by their specific eye-related adverse events, aiding clinical management and research.

Area of Science:

  • Oncology
  • Ophthalmology
  • Pharmacology

Background:

  • Biological therapies are increasingly vital in cancer treatment.
  • Ocular side effects from these therapies are common (up to 70%) but often underreported.
  • Understanding specific side effect profiles linked to biological agents is crucial.

Purpose of the Study:

  • To categorize biological agents based on their associated ocular side effect profiles.
  • To provide a comprehensive overview of ocular adverse events linked to FDA-approved biologicals in oncology.

Main Methods:

  • Conducted extensive database searches (Medline, Cochrane Library, FDA).
  • Utilized specific search strings combining biological agent names with "eye" or "ocular".
  • Further investigated drug-specific side effects through targeted Medline searches.

Main Results:

  • Identified distinct ocular side effect profiles for different groups of biological agents.
  • Compiled a list of ocular side effects associated with FDA-approved oncologic biologicals.
  • Highlighted underreported ocular adverse events in the literature.

Conclusions:

  • Biologicals used in cancer therapy exhibit varied ocular side effect profiles.
  • This categorization aids in predicting and managing potential eye-related adverse events.
  • Further research into the pathophysiology of these ocular side effects is warranted.
Keywords:
EGFRbiologicalinterferonocular side effecttargeted therapy

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