Related Experiment Video
Updated: Aug 4, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
[Anaphylactogenicity of dextran-conjugated serum globulins]
Abstract:
Active anaphylaxis in 238 guinea-pigs has revealed a decrease in the anaphylactogenic activity of horse blood serum IgG conjugates with dextran and of serum treated with dextran according to Diaferm method. The conjugates were used for a challenge injection. The sensitizing activity of dextran-conjugated proteins was higher than that of native proteins. The effect was most pronounced with 150,000 D dextran used as a matrix. A lower increase in sensitizing protein activity and a decrease in anaphylactogenic activity were achieved with dextran matrix of the molecular weight of 35-50 D and protein/dextran ratio from 1:6 to 1:9.
Related Concept Videos
Allergic Reactions
Allergic Drug Reactions
Drug Toxicity: Allergic Reactions
Allergic Reactions: Anaphylaxis
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Hypersensitivity Reactions: Immune-Complex Reactions

