Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Integration of Synaptic Events01:28

Integration of Synaptic Events

6.4K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
6.4K
The Synapse02:47

The Synapse

99.9K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
99.9K
Synaptic Signaling01:09

Synaptic Signaling

5.7K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
5.7K
Synaptic Signaling01:12

Synaptic Signaling

70.0K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
70.0K
Electrical Synapses01:28

Electrical Synapses

10.1K
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
10.1K
Neuronal Communication01:28

Neuronal Communication

5.5K
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A chromosome-level reference genome assembly of the King Ratsnake (Elaphe carinata).

Scientific data·2026
Same author

Deciphering the genetic background of an industrial 2-ketogluconic acid-producing strain Pseudomonas plecoglossicida JUIM01 using whole-genome sequencing.

Biotechnology for biofuels and bioproducts·2026
Same author

Mechanisms of Copper Stress Response in Plants: Implications for the Medicinal Plant <i>Platycodon grandiflorus</i>.

Biology·2026
Same author

Dissecting the propensity of RIM1 subdomains to form phase condensates.

Scientific reports·2026
Same author

WNT4 reprograms dental pulp stem cells to resist PANoptosis and rebuild neurogenic potential for facial nerve injury repair.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2026
Same author

Disentangling complex language contact and admixture in the broad Gansu-Qinghai region.

Fundamental research·2026
Same journal

Correction: Acetylcholine receptor stimulation activates protein kinase C mediated internalization of the dopamine transporter.

Frontiers in cellular neuroscience·2026
Same journal

Defining spinal motor neuron subtypes across development: from embryonic specification to postnatal maturation.

Frontiers in cellular neuroscience·2026
Same journal

Brief mechanical pulses induce sustained intracellular L-lactate production in astrocytes.

Frontiers in cellular neuroscience·2026
Same journal

Effects of ethanol leaf extract of <i>Spondias mombin</i> on scopolamine-induced hippocampal neurodegeneration in adult male Wistar rats: evidence from behavioral, biochemical, histological, and immunohistochemical analyses.

Frontiers in cellular neuroscience·2026
Same journal

Ferroptosis in intracerebral hemorrhage: a bibliometric overview of mechanisms and future directions.

Frontiers in cellular neuroscience·2026
Same journal

<i>Scn2a</i>, encoding Na <sub><i>V</i></sub> 1.2 channel, contributes to tonotopic maturation of spike kinetics in developing mouse MNTB.

Frontiers in cellular neuroscience·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

19.5K

Synaptic integration by NG2 cells.

Wenjing Sun1, Dirk Dietrich1

  • 1Experimental Neurophysiology, Department of Neurosurgery, University Clinic Bonn Bonn, Germany.

Frontiers in Cellular Neuroscience
|January 7, 2014
PubMed
Summary
This summary is machine-generated.

Oligodendrocyte precursor cells (NG2 cells) receive direct synaptic input from neurons. This review explores how these cells integrate neural activity for activity-dependent myelination.

Keywords:
NG2 cellcable modelcalcium signalingdendritessynapses

More Related Videos

Fast Micro-iontophoresis of Glutamate and GABA: A Useful Tool to Investigate Synaptic Integration
07:08

Fast Micro-iontophoresis of Glutamate and GABA: A Useful Tool to Investigate Synaptic Integration

Published on: July 31, 2013

18.9K
In Vivo Direct Reprogramming of Resident Glial Cells into Interneurons by Intracerebral Injection of Viral Vectors
12:26

In Vivo Direct Reprogramming of Resident Glial Cells into Interneurons by Intracerebral Injection of Viral Vectors

Published on: June 17, 2019

11.0K

Related Experiment Videos

Last Updated: May 4, 2026

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

19.5K
Fast Micro-iontophoresis of Glutamate and GABA: A Useful Tool to Investigate Synaptic Integration
07:08

Fast Micro-iontophoresis of Glutamate and GABA: A Useful Tool to Investigate Synaptic Integration

Published on: July 31, 2013

18.9K
In Vivo Direct Reprogramming of Resident Glial Cells into Interneurons by Intracerebral Injection of Viral Vectors
12:26

In Vivo Direct Reprogramming of Resident Glial Cells into Interneurons by Intracerebral Injection of Viral Vectors

Published on: June 17, 2019

11.0K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Glial Cell Biology

Background:

  • NG2 expressing oligodendrocyte precursor cells (NG2 cells) uniquely receive synaptic contacts from neurons.
  • This neuronal input allows NG2 cells to sense neural activity with high precision.
  • The role of this signaling in activity-dependent myelination is hypothesized but not fully understood.

Purpose of the Study:

  • To review the biophysical properties of synaptic currents and membrane characteristics of NG2 cells.
  • To discuss the capacity of NG2 cells for temporal and spatial signal integration.
  • To explore the potential significance of this integration for activity-dependent myelination.

Main Methods:

  • Literature review of biophysical properties of NG2 cells.
  • Analysis of synaptic integration mechanisms in glial cells.
  • Discussion of theoretical models of signal integration.

Main Results:

  • NG2 cells possess biophysical properties enabling sophisticated integration of synaptic inputs.
  • Synaptic currents and membrane properties support precise temporal and spatial signal summation.
  • These integration capabilities are crucial for translating neural activity into myelination signals.

Conclusions:

  • NG2 cells are equipped to integrate complex neural information through their unique synaptic connections.
  • Understanding NG2 cell signal integration is key to elucidating the mechanisms of activity-dependent myelination.
  • This integration highlights a novel pathway for neuron-glia communication impacting brain plasticity.