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TWEAK/Fn14 Axis-Targeted Therapeutics: Moving Basic Science Discoveries to the Clinic

Emily Cheng1, Cheryl L Armstrong1, Rebeca Galisteo1

  • 1Department of Surgery, Center for Vascular and Inflammatory Diseases and Greenebaum Cancer Center, University of Maryland School of Medicine , Baltimore, MD , USA.

Frontiers in Immunology
|January 7, 2014
PubMed
Summary

Tumor necrosis factor-like weak (TWEAK) and its receptor Fn14 (fibroblast growth factor 14) are key in tissue repair and disease. Targeting this TWEAK/Fn14 signaling axis shows therapeutic potential for cancer and inflammatory conditions.

Keywords:
Fn14TWEAKcancerclinical trialinflammatory disease

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