Related Experiment Video
Updated: May 4, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Diagnosis of pediatric nasopharynx carcinoma after recurrent adenoidectomy
Koray Cengiz1, Tolgar Lütfi Kumral2, Güven Yıldırım2
1Department of Otorhinolaryngology-Head and Neck Surgery, Private Gazi Hospital, Sultangazi, Istanbul 34260, Turkey.
Insights
Nasopharyngeal carcinoma (NPC) is rare in children but can mimic adenoid hypertrophy. Surgeons must remain vigilant for suspicious signs during routine adenoidectomy to ensure timely diagnosis of this advanced disease.
Area of Science:
- Otolaryngology
- Pediatric Oncology
- Surgical Pathology
Background:
- Nasopharyngeal soft tissue masses in children are most commonly due to adenoid hypertrophy.
- Nasopharyngeal carcinoma (NPC), though rare in pediatric populations, presents significant diagnostic challenges.
- Common symptoms like nasal obstruction and otitis media often lead to advanced NPC diagnosis.
Purpose of the Study:
- To report a case of pediatric nasopharyngeal carcinoma initially presenting as recurrent adenoid hypertrophy.
- To highlight the importance of considering NPC in the differential diagnosis of persistent nasal obstruction in children.
- To emphasize surgeon awareness of subtle signs during routine procedures.
Main Methods:
- Case report of a 7-year-old boy undergoing recurrent adenoidectomy.
- Intraoperative suspicion of a hard nasopharyngeal mass.
- Histopathological diagnosis of nasopharyngeal carcinoma.
Main Results:
- The patient presented with recurrent nasal obstruction necessitating repeat adenoidectomy.
- A hard mass was discovered during the second operation, leading to NPC diagnosis.
- NPC diagnosis occurred at an advanced stage due to initial presentation mimicking benign conditions.
Conclusions:
- Adenoidectomy is a common procedure where NPC is an unlikely consideration.
- Surgeons must be alert to specific signs and symptoms that warrant suspicion for NPC.
- Early detection of pediatric NPC is crucial, despite its rarity and challenging presentation.
Abstract:
Nasopharyngeal soft tissue is most commonly adenoid hypertrophy in children. Although rare, nasopharyngeal carcinoma (NPC) does occur in children. Nasal obstruction, serous otitis media, hearing problems, and tinnitus are common signs and symptoms of all nasal diseases. For this reason, the majority of NPC presents with advanced disease at the time of the diagnosis. This paper reported 7-year-old boy who was admitted to the hospital for adenoidectomy. He had recurrent adenoidectomy operation due to nasal obstruction. NPC had been diagnosed suspecting the hard mass in the nasopharynx during the operation. Adenoidectomy is the most commonly performed surgical procedure in ENT practice and NPC is unlikely to be considered in the differential diagnosis. Surgeon should be careful about signs and symptoms that alert suspicion.
Related Concept Videos
Suctioning the Nasopharyngeal Airway
Equipment Required
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
