Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MEDUSA: Maintaining Entire DNA Duplexes for Utmost Sequencing Accuracy.

Clinical chemistry·2026
Same author

Genome-wide extraction of differentially methylated DNA regions using adapter-anchored proximity primers.

Nucleic acids research·2026
Same author

MEDUSA: Maintaining Entire DNA Duplexes for Utmost Sequencing Accuracy.

bioRxiv : the preprint server for biology·2025
Same author

The Therapeutic Potential of Photoimmunotherapy as a Safe, Effective and Non-Toxic Treatment Option for Superficial Triple Negative Breast Cancer.

Cancer medicine·2025
Same author

Measurable residual disease detection after CAR-T may predict response in patients with large B-cell lymphoma.

Blood advances·2025
Same author

Genome-wide extraction of differentially methylated DNA regions using adapter-anchored proximity primers.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: May 4, 2026

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

1.8K

Third generation gold nanoplatform optimized for radiation therapy.

Rajiv Kumar1, Houari Korideck2, Wilfred Ngwa2

  • 1Electronic Materials Research Institute and Department of Physics, Northeastern University, Boston, MA, USA ; Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Translational Cancer Research
|January 7, 2014
PubMed
Summary

We developed AuRad™, ultrasmall gold nanoparticles for radiation therapy. These nanoparticles show enhanced cancer cell killing and can be used for imaging and drug delivery, acting as a theranostic agent.

Keywords:
Gold nanoparticlesPEGylationclonogenic assaymultifunctional nanoparticlesradiation therapy

More Related Videos

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods
10:46

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods

Published on: May 2, 2016

6.3K
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
09:09

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

5.6K

Related Experiment Videos

Last Updated: May 4, 2026

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

1.8K
Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods
10:46

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods

Published on: May 2, 2016

6.3K
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
09:09

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

5.6K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Radiotherapy

Background:

  • Gold nanoparticles offer unique properties for medical applications.
  • Developing advanced nanocarriers is crucial for improving cancer treatment efficacy.
  • Theranostic agents combine diagnostic and therapeutic capabilities.

Purpose of the Study:

  • To design and fabricate a third-generation ultrasmall PEGylated gold nanoparticle platform (AuRad™) for radiation therapy.
  • To optimize the nanoplatform for enhanced tumor uptake, circulation time, and clearance.
  • To evaluate the theranostic potential of AuRad™ in preclinical models.

Main Methods:

  • Synthesis of 2-3 nm gold nanoparticles.
  • Surface functionalization with hetero-bifunctional PEG (amine, carboxyl, methoxy groups).
  • Conjugation of AlexaFluor 647 for optical imaging.
  • In vitro cell uptake studies using confocal bioimaging (HeLa cells).
  • Radiation enhancement evaluation using clonogenic survival assays with X-ray irradiation.

Main Results:

  • AuRad™ nanoparticles demonstrated high stability (>6 months).
  • Confocal bioimaging confirmed robust cellular uptake in HeLa cells.
  • X-ray irradiation resulted in a >2.8-fold enhancement in cancer cell kill.
  • The nanoplatform exhibited versatility for conjugating various moieties.

Conclusions:

  • AuRad™ is a stable, biocompatible, and highly effective nanoplatform for radiation therapy.
  • The ultrasmall size and PEGylation optimize pharmacokinetic properties for enhanced tumor targeting.
  • AuRad™ shows significant potential as a theranostic agent, improving radiation therapy outcomes.