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Plasma free Fatty Acid concentrations as a marker for acute myocardial infarction
Vijay Kumar Roy1, Anil Kumar1, Prabal Joshi2
1Assistant Professor, Departement of Physiology, SGT Medical College, Hospital & Reaserch Institute , Budhera, Gurgaon-122505, Haryana, India .
Insights
Plasma free fatty acid (FFA) levels significantly increase within 24 hours of acute myocardial infarction, then normalize by day seven. This finding suggests FFA could be a useful biomarker for diagnosing heart attacks.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Acute myocardial infarction (AMI) is a leading cause of cardiac mortality.
- Biomarkers like CPK and LDH aid in diagnosing myocardial necrosis.
- Continuous research seeks improved diagnostic and management parameters for Coronary Artery Diseases (CAD).
Purpose of the Study:
- To investigate the relationship between plasma free fatty acid (FFA) concentration and acute myocardial infarction.
- To assess FFA as a potential diagnostic marker for AMI.
Main Methods:
- A study involving 50 acute myocardial infarction patients (25 male, 25 female) aged 40-70.
- A control group of 50 age-matched subjects.
- Plasma FFA concentration measured using a modified Trout et al. titrimetric method.
Main Results:
- A statistically significant increase in plasma FFA was observed within the first 24 hours post-AMI.
- Plasma FFA levels showed a subsequent normalization by the seventh day.
- The difference in FFA levels between day one and day seven was statistically significant.
Conclusions:
- Elevated plasma FFA levels are associated with acute myocardial infarction.
- Routine estimation of serum free fatty acid is recommended for early diagnosis of AMI.
Background:
Acute myocardial infarction carries a high mortality among cardiac patients.The discovery of the fact that certain enzymes like CPK, LDH liberated into circulation following necrosis of the myocardial cells came as boon for physicians and patients. There has been a constant search of different parameters for the diagnosis and management of CoronaryArtery Diseases (CAD).
Aim:
The present study was undertaken to investigate a possible relation between the changes in plasma free fatty acid (FFA) concentration and acute myocardial infarction.
Material And Methods:
Fifty cases (25 males and 25 females) of acute myocardial infarction were selected for the present study. All the patients were in the age group of 40-70 years. For the control group fifty (25 male and 25 female) subjects of same age group were selected from patient's relatives and friends. Plasma free fatty acid concentration was estimated by Titrametric method of Trout et al., (1960), a modified version of Dole (1956).
Statistical Analysis:
The statistical analysis of the data of the present study was done by using SPSS, version 14.0.1 was used.
Results:
Our study showed a significant increase in plasma FFA in the first 24 hours of acute myocardial infarction with subsequent normalisation on the 7th day.The difference between the first and the seventh day was statistically significant.
Conclusion:
The FFA were found raised in cases of acute myocardial infarction.On the basis of present study, it is worth to say that estimation of serum free fatty acid should be done routinely at the earliest opportunity in all cases of acute myocardial infarction.
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