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Updated: May 4, 2026
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Rat Mesentery Exteriorization: A Model for Investigating the Cellular Dynamics Involved in Angiogenesis
Published on: May 20, 2012
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Endoplasmic reticulum stress and angiogenesis: is there an interaction between them?
Annelies Paridaens1, Debby Laukens, Yves-Paul Vandewynckel
1Department of Gastroenterology and Hepatology, Ghent University, Ghent, Belgium.
Summary
Cellular endoplasmic reticulum (ER) stress triggers the unfolded protein response (UPR), impacting blood vessel growth (angiogenesis). This review explores the UPR-angiogenesis link in diseases like chronic liver diseases (CLDs).
Area of Science:
- Cellular Biology
- Molecular Medicine
- Pathophysiology
Background:
- Cellular stress leads to unfolded protein accumulation in the endoplasmic reticulum (ER).
- This accumulation triggers the unfolded protein response (UPR), a protective cellular mechanism.
- Both UPR and angiogenesis are implicated in various disease pathologies.
Purpose of the Study:
- To review the interplay between the unfolded protein response (UPR) and angiogenesis.
- To examine this interaction in physiological conditions and diverse diseases, particularly chronic liver diseases (CLDs).
Main Methods:
- Literature review of recent research on UPR and angiogenesis.
- Synthesis of findings related to UPR-angiogenesis axis in disease pathogenesis.
- Focus on chronic liver diseases (CLDs) including alcoholic liver disease, NASH, and hepatitis B.
Main Results:
- The UPR-angiogenesis axis plays a significant role in the development of various diseases.
- Dysregulation of UPR and angiogenesis contributes to the pathophysiology of CLDs.
- Understanding this interaction offers insights into disease mechanisms.
Conclusions:
- The UPR and angiogenesis are closely interconnected in both health and disease.
- Targeting the UPR-angiogenesis pathway may offer therapeutic strategies for CLDs and other conditions.
- Further research is needed to fully elucidate this complex relationship.
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