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Published on: September 15, 2023
Expression of B-cell-specific Moloney murine leukemia virus integration site 1 mRNA and protein in gastric cancer
Peng Wei Liu1, Yun Lin, Xiao Yu Chen
1Department of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Division of Gastrointestinal Pathology, Shanghai Institute of Digestive Disease, Shanghai, China.
Objective:
To investigate the role of B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) in gastric cancer (GC) and its relationship with the clinicopathological features of GC.
Methods:
Laser capture microdissection combined with real-time polymerase chain reaction and Western blot were used to determine the expressions of Bmi-1, the cellular homologue of avian myelocytomatosis virus (c-Myc), enhancer of Zeste homolog 2 (EZH2), phosphatase and tensin homologue (PTEN) and epithelial cadherin (E-cadherin) in 20 GC specimens and the adjacent non-cancerous gastric tissues.
Results:
The mRNA and protein expressions of Bmi-1 in GC were increased compared with those of the non-cancerous gastric tissues (P = 0.012 and P = 0.000, respectively). Bmi-1 mRNA expression was positively correlated with tumor size, degree of tumor differentiation, invasion and lymph node metastasis. At both mRNA and protein levels, Bmi-1 was positively correlated with c-Myc and EZH2, but negatively correlated with PTEN and E-cadherin.
Conclusion:
Bmi-1 might be involved in GC at both transcription and translation levels.
