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Related Experiment Videos

Mutual tolerization of histoincompatible lymphocytes.

H G Rammensee, M J Bevan

    European Journal of Immunology
    |June 1, 1987
    PubMed
    Summary
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    Peripheral T cells eliminate self-reactive cytotoxic T lymphocytes (CTL) through a failsafe mechanism. This process prevents autoimmune responses by removing autoreactive CTL in the periphery.

    Area of Science:

    • Immunology
    • Transplantation Immunology
    • T cell biology

    Background:

    • T lymphocytes exhibit strong reactivity against foreign Major Histocompatibility Complex (MHC) class I antigens, leading to tissue rejection and cytotoxic T lymphocyte (CTL) generation.
    • Self-tolerance is primarily established through clonal deletion of self-reactive T cells in the thymus.
    • Peripheral mechanisms for eliminating self-reactive T cells, such as functional clonal deletion of CTL recognizing other CTL, have been recently described.

    Purpose of the Study:

    • To investigate the existence and function of a peripheral failsafe mechanism for eliminating autoaggressive cytotoxic T lymphocytes (CTL).
    • To determine if introducing foreign lymphocytes into an incompatible host can abrogate host anti-donor and donor anti-host reactivity.

    Main Methods:

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  • Injection of lymphocytes into class I-incompatible mouse models.
  • Assessment of host anti-donor and donor anti-host reactivity.
  • Analysis of T cell populations and their reactivity against third-party antigens.

    • Main Results:

    • Injection of lymphocytes into class I-incompatible mice resulted in the abrogation of both host anti-donor and donor anti-host reactivity.
    • A mixed population of host and donor T cells, reactive against third-party antigens but not against each other, was observed.
    • These findings demonstrate a peripheral failsafe mechanism that eliminates autoaggressive CTL.

    Conclusions:

    • A peripheral failsafe mechanism exists for the elimination of autoaggressive cytotoxic T lymphocytes (CTL).
    • This mechanism contributes to maintaining self-tolerance in the periphery by preventing autoimmune CTL responses.
    • Further investigation is needed to determine the physiological relevance of this failsafe mechanism under natural conditions.