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Author Spotlight: Optimizing Growth Factors for Production of Biotechnologically Relevant Secondary Metabolites
Published on: October 25, 2024
The influence of sulfathiazole on the macroalgae Ulva lactuca
Sara Leston1, Margarida Nunes1, Ivan Viegas2
1CFE - Centre for Functional Ecology, Department of Life Sciences, University of Coimbra, Apartado 3046, 3001-401 Coimbra, Portugal; CEF - Center for Pharmaceutical Studies, Health Sciences Campus, Pharmacy Faculty, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
Abstract:
Sulfonamides (SA) are a class of antibiotics routinely found in environmental matrices and therefore their role as contaminants should be investigated in non-target organisms. With this purpose the present experimental work has evaluated the exposure of the chlorophycean Ulva lactuca L. to sulfathiazole (STZ), a SA drug commonly used in aquaculture, at two concentrations representing prophylactic (25 μg mL(-1)) and therapeutic (50 μg mL(-1)) administrations. Results showed that STZ exhibits high stability in seawater with only 18% degradation over the 5d assay at both dosages tested. Also, macroalgae demonstrated an efficient uptake capacity with constant internal concentrations after 24h regardless of the external solutions and thus should be considered as a bioindicator species in risk assessment. Both STZ concentrations induced a slight inhibition of the macroalgae growth after 96 h.
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