[A case of advanced sigmoid colon cancer successfully treated with multimodality therapy]

A 61-year-old man underwent sigmoidectomy with partial cystectomy for advanced sigmoid colon cancer with unresectable multiple liver metastases at the Okayama University Hospital in June 2006. Pathological examination revealed moderately differentiated adenocarcinoma, pStage IV( pSI[ bladder], pN0, pH2, pP0, pM0), as per the Japanese Classification of Colorectal Carcinoma, seventh edition. The patient underwent systematic chemotherapy with irinotecan, 5-fluorouraci( l 5-FU), and folinic acid( FOLFIRI) and oxaliplatin, Leucovorin, and 5-FU( mFOLFOX6) for 13 months. In July 2007, hepatectomy was performed as the liver metastatic lesions had shrunk to a resectable size. Follow-up computed tomography (CT) in November 2009 revealed recurrence in the liver and lung. Subsequently, lateral segmentectomy was performed for the recurrent liver lesions, and radiofrequency ablation( RFA) was performed for the lung lesions. After having undergone RFA, the patient is doing well without any re-recurrence. We encountered a patient with advanced sigmoid colon cancer who was successfully treated with multimodality therapy. For patients with advanced or recurrent colorectal cancers, curative resection can lead to a good prognosis; however, in most patients, it is difficult to achieve curative resection by upfront surgery. Multimodality therapy could facilitate curative resection, thereby resulting in a good prognosis.