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Updated: May 4, 2026
Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
Published on: October 27, 2014
[Analysis of weekly paclitaxel chemotherapy for esophageal cancer]
Junji Kawada1, Masashige Nishimura, Yuki Matsui
1Dept. of Surgery, Osaka General Medical Center.
Purpose:
Public knowledge-based application for paclitaxe(l PAC) has been approved for advanced or recurrent esophageal cancer. We investigated the feasibility of weekly PAC chemotherapy as a second-line or subsequent regimen for metastatic or recurrent esophageal cancer.
Materials And Methods:
Patients received PAC( 100 mg/m2 intravenously) on days 1, 8, 15, 22, 29, and 36 of each 8-week period. We analyzed the toxicity and efficacy in 6 patients treated with the weekly PAC chemotherapy.
Results:
Grade 3-4 toxicities were neutropenia, leukopenia, and anemia. Two patients had stable disease and 2 had progressive disease.
Conclusion:
By managing the side effects, weekly PAC therapy is considered a feasible regimen that can be administered on an outpatient basis.
