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[The relationship between malnutrition and immune].

Dimitrios Iliakis¹, Reto W Kressig¹

¹Universitäres Zentrum für Altersmedizin Basel, Felix Platter-Spital, Basel.

Therapeutische Umschau. Revue Therapeutique

|January 8, 2014

Summary

Malnutrition and infection weaken the immune system, increasing disease risk. Optimal nutrition is vital for a robust immune response, especially during aging.

Area of Science:

Immunology
Nutritional Science
Gerontology

Context:

Malnutrition is a leading cause of immunodeficiency globally.
Infections exacerbate nutritional deficiencies, creating a detrimental cycle.
Aging also impacts immune function, particularly T-cell responses.

Purpose:

To elucidate the synergistic effects of malnutrition and aging on immune function.
To highlight the impact of malnutrition on both specific and non-specific immunity.
To emphasize the importance of nutritional status for healthy aging.

Summary:

Malnutrition severely impairs immune responses, increasing susceptibility to infections.
Protein-energy malnutrition (PEM) disproportionately affects non-specific and cell-mediated immunity.

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Aging is associated with diminished T-cell functions and a shift towards anti-inflammatory responses.

Impact:

Understanding these interactions is crucial for public health strategies.
Optimal nutritional status is essential for maintaining immune competence throughout life.
Interventions targeting nutrition may mitigate age-related immune decline and infection risk.