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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Author Spotlight: Advancements in 3D Optical Imaging for Comprehensive Body Composition Assessment in Modern Research
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Body composition and the aged: what needs to be measured?

B Steen1, I Gause-Nilsson, I Bosaeus

  • 1Department of Geriatric Medicineb, Goteborg University, Gothenburg, Sweden.

Asia Pacific Journal of Clinical Nutrition
|January 8, 2014
PubMed
Summary
This summary is machine-generated.

Geriatric body composition was studied for decades in Gothenburg using advanced methods. Researchers tracked changes in older adults over time to understand aging body changes.

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Area of Science:

  • Gerontology and Geriatric Medicine
  • Body Composition Analysis
  • Aging Research

Background:

  • Long-term body composition studies are crucial for understanding aging.
  • Gothenburg has a history of gerontological research, including body composition.

Purpose of the Study:

  • To present findings from decades of body composition research in elderly populations.
  • To highlight methodologies used in assessing body composition in aging individuals.

Main Methods:

  • Utilized a four-compartment model with whole-body potassium 40 counting and isotope-labeled water dilution.
  • Employed bioelectrical impedance analysis and in vivo neutron activation for total body nitrogen determination.
  • Analyzed data from longitudinal studies of individuals aged 70 and 75.

Main Results:

  • Demonstrated the application of multiple advanced techniques for body composition assessment in the elderly.
  • Provided insights into body composition changes over time in aging populations.
  • Showcased the integration of various methods for comprehensive geriatric body composition analysis.

Conclusions:

  • Longitudinal body composition studies in aging populations provide valuable insights.
  • Advanced methodologies are essential for accurate assessment of body composition in geriatrics.
  • Continued research in this area is vital for understanding and supporting healthy aging.