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Papillary Dermis01:11

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Follicular induction overlying a dermatofibrosarcoma protuberans.

Hai-Jin Park1, Jennifer V Nguyen, Christopher J Miller

  • 1*Department of Dermatology, Ilsan Paik Hospital, Inje University School of Medicine, Goyang, South Korea; †Department of Dermatology, University of Pennsylvania, Philadelphia, PA; and ‡Department of Pathology, Main Line Pathology Associates, Bryn Mawr Hospital, Bryn Mawr, PA.

The American Journal of Dermatopathology
|January 8, 2014
PubMed
Summary
This summary is machine-generated.

Follicular induction, an epidermal change, is typically seen with benign skin lesions. However, this study reports a rare case of follicular induction occurring over a malignant tumor, dermatofibrosarcoma protuberans (DFSP).

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Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Follicular induction describes epidermal changes overlying skin lesions.
  • This phenomenon is commonly associated with benign conditions like dermatofibroma (DF).
  • Dermatofibrosarcoma protuberans (DFSP) is a malignant tumor often presenting with atrophic or ulcerated overlying epidermis.

Observation:

  • A rare case of DFSP exhibiting follicular induction of the overlying epidermis is presented.
  • This finding contrasts with the typical epidermal changes observed in DFSP.

Findings:

  • Follicular induction, usually linked to benign lesions, was observed in a malignant DFSP.
  • This rare occurrence can mimic benign changes, posing a diagnostic challenge.

Implications:

  • The presence of follicular induction in DFSP may lead to misdiagnosis, especially in superficial biopsies.
  • Recognizing this rare presentation is crucial for accurate diagnosis and appropriate patient management.
  • This case highlights the importance of considering malignant differentials even with seemingly benign epidermal changes.