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Upper gastrointestinal tract disease and probiotics
1Food Microbiologist Department of Medicine Mornington Peninsula Hospital, Victoria, Australia.
Asia Pacific Journal of Clinical Nutrition
|January 8, 2014
Summary
This review explores upper gastrointestinal tract microflora, focusing on lactic acid bacteria and acid suppression. Probiotics show potential for preventing and treating conditions like peptic ulcers and H. pylori infection.
Area of Science:
- Gastroenterology
- Microbiology
- Microbiome Research
Background:
- Upper gastrointestinal diseases are prevalent.
- The upper GI tract harbors a complex microflora.
- Acid suppression therapy alters the gastric environment.
Purpose of the Study:
- To review the microflora of the upper gastrointestinal tract.
- To highlight the role of lactic acid bacteria.
- To examine the impact of acid suppression on microflora and probiotic efficacy.
Main Methods:
- Literature review of studies on upper GI microflora.
- Analysis of research on lactic acid bacteria in the stomach and duodenum.
- Evaluation of evidence for probiotic survival and function in the upper GI tract.
Main Results:
- Lactic acid bacteria are key components of upper GI microflora.
- Probiotics can survive and exert beneficial effects in the acidic upper GI environment.
- Acid suppression influences microbial composition and may enhance probiotic activity.
Conclusions:
- Probiotics hold promise for the prevention and treatment of upper GI diseases.
- Potential applications include managing peptic ulcer disease, Helicobacter pylori infection, and gastric cancer.
- Further research is warranted to optimize probiotic use in conjunction with acid suppression therapy.
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