Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphologic observations on experimental subretinal neovascularization in the monkey.

T Ishibashi, H Miller, G Orr

    Investigative Ophthalmology & Visual Science
    |July 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Preparation and Characterization Challenges to Understanding Environmental and Biological Impacts of Nanoparticles.

    Surface and interface analysis : SIA·2013
    Same author

    Safe and consistent method of spot-welding platinum thermocouple wires and foils for high temperature measurements.

    The Review of scientific instruments·2012
    Same author

    Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions.

    The Journal of physiology·2005
    Same author

    Using a 360 degrees diagnostic screening tool to provide an evidence trail of junior doctor performance throughout their first postgraduate year.

    Medical teacher·2005
    Same author

    E-mentoring: does it have a place in medicine?

    Postgraduate medical journal·2005
    Same author

    A costed profile audit of the surgical management of female stress incontinence.

    Scottish medical journal·2005

    Subretinal neovascularization, a key feature in eye diseases, was studied using laser photocoagulation in primates. This research details the rapid formation of new blood vessels in the choroid and subretinal space.

    Area of Science:

    • Ophthalmology
    • Vascular Biology
    • Cell Biology

    Background:

    • Subretinal neovascularization is a poorly understood complication in various eye diseases.
    • Understanding its pathogenesis is crucial for developing effective treatments.

    Purpose of the Study:

    • To elucidate the sequential events leading to subretinal neovascularization.
    • To investigate the cellular mechanisms of new blood vessel formation in the primate retina and choroid.

    Main Methods:

    • Light and electron microscopy were employed.
    • A laser photocoagulation model in primate eyes was utilized.
    • The temporal progression of vascular changes was analyzed.

    Main Results:

    • Within 24 hours, choroidal capillaries, venules, and arterioles showed endothelial cell degeneration and thrombus formation.

    Related Experiment Videos

  • Re-endothelialization and endothelial cell migration within existing basement membranes were observed by day two.
  • By day three, endothelial cell budding and lumen formation occurred in both pre-existing and re-endothelialized vessels.
  • New vessels extended into the subretinal space between five and eight days post-photocoagulation.

    • Conclusions:

    • The study reveals a rapid, multi-step process of neovascularization following laser injury.
    • Endothelial cell activation, migration, proliferation, and lumen formation are key events.
    • This primate model provides insights into the cellular dynamics of subretinal neovascularization.