Related Experiment Video For CB
Updated: May 4, 2026
Dissection of Local Ca2+ Signals in Cultured Cells by Membrane-targeted Ca2+ Indicators
Published on: March 22, 2019
Co-localization of L-type voltage dependent calcium channel alpha 1D subunit (Ca(v)1.3) and calbindin (CB) in the
Jie Hua Xu1, Zhen Bang Yang2, Hui Wang3
1Department of Anatomy and Histology, Xi'an Jiaotong University College of Medicine, Xi'an 710061, People's Republic of China.
Abstract:
Previous study has shown that the co-localization of calbindin (CB) with L-type voltage dependent Ca(2+) channel (VDCC) alpha 1C subunit (Ca(v)1.2) in the rat insulinoma 1046-38 (RIN) beta cells may play an important regulatory role in Ca(2+) influx and exocytosis of insulin granules. In the present study, L-type voltage dependent Ca(2+) channel (VDCC) and calbindin (CB) were demonstrated in different regions of the mouse central nervous system (CNS). Double labeling immunofluorescence staining showed a co-localization of Ca(v)1.3 and CB. The co-localization of Ca(v)1.3 and CB in certain brain regions such as the hippocampus suggests their important roles in neuroplasticity. The relative high percentages of co-localization of Ca(v)1.3 with CB in the laminae II of the dorsal horn of the spinal cord indicate that the regulation mechanism of nociceptive transmission may be related with both VDCC and Ca(2+) binding protein.
