Improvements in instrumentation for thermospray operation on a magnetic sector mass spectrometer

Changes in the design of a thermospray liquid chromatography-mass spectrometry ion source can be made to improve the sensitivity towards solute related ions and therefore extend the practical utility of the complete system. The addition of a discharge ionization facility provides much greater scope for gradient elution analyses and forms the basis of a method which offers increased structural information. All of these changes are illustrated by practical examples.