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Updated: May 4, 2026
Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
TET family proteins: new players in gliomas
Er-Bao Bian1, Gang Zong, Yong-Sheng Xie
1Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Abstract:
DNA methylation at the 5-position of cytosine (5mC) in the mammalian genome has emerged as a pivotal epigenetic event that plays important roles in development, aging and disease. The three members of the TET protein family, which convert 5mC to 5-hydroxymethylcytosine, has provided a potential mechanism resulting in DNA demethylation and maintaining cellular identity. Recent studies have shown that epigenetic modifications play a key role in the regulation of the molecular pathogenesis of gliomas. In this review we focus on demonstrating the TET proteins in DNA demethylation and transcriptional regulation of different target genes. In addition, we address the role of TET proteins in gliomas. This review will provide valuable insights into the potential targets of gliomas, and may open the possibility of novel therapeutic approaches to this fatal disease.
Insights
Ten-eleven translocation (TET) proteins are crucial for DNA demethylation and regulating gene expression. This review explores their role in glioma pathogenesis, offering insights into potential therapeutic strategies for this fatal disease.
Area of Science:
- Epigenetics
- Molecular Biology
- Oncology
Background:
- DNA methylation (5mC) is a key epigenetic mark involved in development, aging, and disease.
- Ten-eleven translocation (TET) proteins catalyze the conversion of 5mC to 5-hydroxymethylcytosine (5hmC), mediating DNA demethylation.
- Epigenetic modifications, including DNA methylation, are implicated in the molecular pathogenesis of gliomas.
Purpose of the Study:
- To review the function of TET proteins in DNA demethylation and transcriptional regulation.
- To elucidate the role of TET proteins in the pathogenesis of gliomas.
- To highlight potential therapeutic targets and strategies for glioma treatment.
Main Methods:
- Literature review focusing on studies of TET proteins, DNA demethylation, and glioma.
- Analysis of the mechanisms by which TET proteins regulate gene expression.
- Synthesis of current knowledge on TET protein involvement in glioma development and progression.
Main Results:
- TET proteins are central to the dynamic regulation of DNA methylation and demethylation.
- TET proteins influence the transcriptional landscape by modifying epigenetic marks.
- Dysregulation of TET proteins is associated with glioma development and progression.
Conclusions:
- TET proteins play a significant role in DNA demethylation and transcriptional regulation.
- Understanding TET protein function in gliomas is critical for developing novel therapies.
- Targeting TET proteins may offer a promising therapeutic avenue for treating gliomas.
