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Updated: May 4, 2026

High-definition Fourier Transform Infrared FT-IR Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology
Published on: January 21, 2015
Attenuated total reflection fourier transform infrared (ATR-FTIR) spectral discrimination of brain tumour severity
James R Hands1, Konrad M Dorling, Peter Abel
1Centre for Materials Science, Division of Chemistry, JB Firth Building, University of Central Lancashire, Preston, PR1 2HE, UK.
Abstract:
Gliomas are the most frequent primary brain tumours in adults with over 9,000 people diagnosed each year in the UK. A rapid, reagent-free and cost-effective diagnostic regime using serum spectroscopy would allow for rapid diagnostic results and for swift treatment planning and monitoring within the clinical environment. We report the use of ATR-FTIR spectral data combined with a RBF-SVM for the diagnosis of gliomas (high-grade and low-grade) from non-cancer with sensitivities and specificities on average of 93.75 and 96.53% respectively. The proposed diagnostic regime has the ability to reduce mortality and morbidity rates.
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