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Updated: May 4, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis, antioxidant, and cytotoxic activities of N-azole substituted thiomorpholine derivatives
Putta Ramachandra Reddy1, Guda Mallikarjuna Reddy, Adivireddy Padmaja
1Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
Abstract:
A new class of N-azole substituted thiomorpholine derivatives were prepared and their antioxidant and cytotoxic activities were studied. The methyl substituted oxazolyl thiomorpholine dioxide 9b exhibited radical scavenging activity greater than the standard ascorbic acid. On the other hand, the thiazolyl thiomorpholine 10c having a chloro substituent on the aromatic ring was identified as a remarkable lead molecule for cytotoxic activity against A549 and HeLa cells, with IC50 values of 10.1 and 30.0 µM, respectively.
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