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Published on: August 21, 2014
Genomic lens on neuroglobin transcription
Santina Cutrupi1, Giulio Ferrero, Stefania Reineri
1Center for Molecular Systems Biology, University of Turin, Orbassano, Turin, Italy; Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy.
Abstract:
Neuroglobin is a brain globin with neuroprotective effects against ischemia and related pathological processes, acting as O2 sensor and antiapoptotic pathway transducer. Here, we survey data on neuroanatomical coexpression of transcription factors, epigenetic signature and predictive transcription factor binding sites at the neuroglobin gene locus to find hints of pathways to neuroglobin transcriptional regulation. These data provide a glimpse of how neuroglobin expression may translate into neuronal diversity and function, as well as disease.
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