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SUMO Ubc9 enzyme as a viral target
Archana Varadaraj1, Domenico Mattoscio, Susanna Chiocca
1Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
IUBMB Life
|January 8, 2014
Summary
Viruses target the SUMO conjugating enzyme Ubc9 to disrupt host defenses. This review details viral strategies to deregulate Ubc9, enhancing viral persistence and propagation.
Area of Science:
- Molecular Biology
- Virology
- Biochemistry
Background:
- Viruses manipulate host cell processes to ensure survival and replication.
- The SUMO conjugating enzyme Ubc9 is crucial for protein sumoylation and interactions.
- Ubc9's dual role makes it a key target for viral interference.
Purpose of the Study:
- To review the mechanisms viruses employ to deregulate Ubc9.
- To understand how viral targeting of Ubc9 impacts host-pathogen interactions.
- To explore the consequences of Ubc9 manipulation on viral persistence.
Main Methods:
- Literature review of viral-host interactions.
- Analysis of molecular mechanisms of Ubc9 regulation by viruses.
- Examination of protein sumoylation and interaction pathways.
Main Results:
- Viruses employ diverse strategies to inhibit or hijack Ubc9 function.
- Deregulation of Ubc9 disrupts host antiviral responses.
- Targeting Ubc9 facilitates viral replication and persistence.
Conclusions:
- Viral interference with Ubc9 is a common and effective strategy.
- Understanding these mechanisms can reveal new antiviral targets.
- Ubc9 is a critical node in host-pathogen interactions.
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