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Tissue penetration of antifungal agents

Timothy Felton1, Peter F Troke, William W Hope

  • 1The University of Manchester, Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom.

Clinical Microbiology Reviews
|January 8, 2014
PubMed

Insights

Systemic antifungal drug concentrations in tissues, not just blood, are key for effective treatment. This review details drug distribution and therapeutic implications for invasive fungal infections.

Area of Science:

  • Pharmacology
  • Mycology
  • Infectious Diseases

Background:

  • Antifungal efficacy depends on tissue drug penetration, which can differ from blood levels.
  • Invasive fungal infections have varied pathogenesis, influencing drug concentration interpretation.
  • Estimating antifungal concentrations in tissue subcompartments presents technical challenges.

Purpose of the Study:

  • To review tissue penetration and distribution of systemic antifungal agents.
  • To summarize tissue concentrations of 11 licensed systemic antifungal drugs.
  • To explore therapeutic implications of antifungal drug distribution in various infection sites.

Main Methods:

  • Literature review of systemic antifungal agents.
  • Analysis of pharmacokinetic data focusing on tissue distribution.
  • Synthesis of information on 11 currently licensed systemic antifungal agents.

Main Results:

  • Systemic antifungal agents exhibit diverse tissue distribution patterns.
  • Tissue concentrations and their time course can significantly deviate from plasma concentrations.
  • Understanding drug distribution is crucial for optimizing antifungal therapy.

Conclusions:

  • Tissue penetration is a critical factor in antifungal drug efficacy.
  • Variability in tissue distribution impacts treatment strategies for invasive fungal infections.
  • Further research into antifungal drug tissue pharmacokinetics is warranted.

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