Related Experiment Video
Updated: May 4, 2026
04:46
Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations
Published on: February 24, 2023
4.5K
Relapsing intracranial plasma cell granuloma: A case report
Jaclyn J Renfrow1, Jerry W Mitchell2, Michael Goodman3
1Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Oncology Letters
|January 8, 2014
Summary
Intracranial plasma cell granuloma, a rare condition, can recur. This case report details a 14-year follow-up, highlighting the erythrocyte sedimentation rate as a useful marker for monitoring disease activity.
Area of Science:
- Neuropathology
- Oncology
- Inflammatory Diseases
Background:
- Plasma cell granuloma is a rare pathological entity, particularly within the cranial cavity.
- Intracranial plasma cell granuloma presents unique diagnostic and management challenges due to its rarity.
Purpose of the Study:
- To present a rare case of intracranial plasma cell granuloma.
- To report the longest known follow-up period for an intracranial plasma cell granuloma case.
- To describe the clinical utility of erythrocyte sedimentation rate in monitoring disease recurrence and therapeutic response.
Main Methods:
- Case report with 14-year medical follow-up.
- Details of treatment including craniotomies, radiation therapy, and glucocorticoid therapy.
- Disease surveillance via clinical examination, imaging, and erythrocyte sedimentation rate monitoring.
Main Results:
- The patient experienced four recurrences of intracranial plasma cell granuloma over 14 years.
- Treatment involved multiple interventions: three craniotomies, 3,600-cGy radiation, and two courses of glucocorticoids.
- Erythrocyte sedimentation rate changes correlated with disease recurrence and response to treatment, demonstrating its clinical utility.
Conclusions:
- Intracranial plasma cell granuloma requires long-term surveillance due to potential for recurrence.
- A multidisciplinary treatment approach is often necessary for managing intracranial plasma cell granuloma.
- Erythrocyte sedimentation rate serves as a valuable, non-invasive biomarker for monitoring disease activity in intracranial plasma cell granuloma.
Related Concept Videos
01:26Brain Abscess l: Introduction
21
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...
21
01:29Increased Intracranial Pressure ll: Pathophysiology
20
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins...
20
01:14Increased Intracranial Pressure l: Introduction
27
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component...
27