Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

23
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence...
23
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

30
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
30
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

26
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor,...
26
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

28
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...
28
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

26
Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
26
Autoimmune Disorders01:29

Autoimmune Disorders

2.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Association Between Serum C-Reactive Protein Levels and Body Fat Parameters: Results from the Korean National Health and Nutrition Examination Survey.

Medicina (Kaunas, Lithuania)·2026
Same author

Remotely sensed evapotranspiration-based ensemble streamflow modeling in an ungauged watershed under climate and land use/cover change, North Korea.

Journal of environmental management·2026
Same author

Rheumatoid arthritis is associated with chronic dizziness, recurrent falls, and chronic imbalance: results from the Korean National Health and Nutrition Examination Survey.

Advances in rheumatology (London, England)·2026
Same author

Physical Activity and Liver Fibrosis: A Stratified Analysis by Obesity and Diabetes Status.

Journal of clinical medicine·2026
Same author

First Report of Lipoprotein X Formation in Methimazole-Induced Cholestatic Jaundice with Agranulocytosis.

Annals of laboratory medicine·2026
Same author

Iodine Intake and Risk of Mortality: Evidence from a Nationally Representative Korean Cohort.

Nutrients·2025

Related Experiment Video

Updated: May 4, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.8K

Steroid responsive xanthomatous hypophysitis associated with autoimmune thyroiditis: a case report.

Ji Young Joung1, Hyemin Jeong1, Yoon Young Cho1

  • 1Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Endocrinology and Metabolism (Seoul, Korea)
|January 8, 2014
PubMed
Summary

This case study details xanthomatous hypophysitis, a rare pituitary condition. High-dose glucocorticoid therapy effectively reduced the residual mass and improved symptoms, suggesting its potential as a treatment option.

Keywords:
GlucocorticoidsThyroiditis, autoimmuneXanthomatous hypophysitis

More Related Videos

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

13.9K
Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

11.1K

Related Experiment Videos

Last Updated: May 4, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.8K
Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

13.9K
Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

11.1K

Area of Science:

  • Endocrinology
  • Neurology
  • Pathology

Background:

  • Xanthomatous hypophysitis is a rare inflammatory condition affecting the pituitary gland.
  • It can present with symptoms of hypopituitarism, headache, and visual disturbances.
  • The exact pathophysiology remains unclear, but an autoimmune basis is suspected.

Purpose of the Study:

  • To report a case of xanthomatous hypophysitis in a 36-year-old woman.
  • To describe the diagnostic findings, including imaging and histology.
  • To evaluate the treatment response to surgical resection and high-dose glucocorticoid therapy.

Main Methods:

  • A 36-year-old woman presented with headache, fever, and amenorrhea.
  • Investigations included laboratory tests, cerebrospinal fluid analysis, and MRI.
  • Surgical resection via endoscopic transsphenoidal approach was performed, followed by methylprednisolone pulse therapy.

Main Results:

  • Histopathology confirmed xanthomatous hypophysitis with foamy histiocytes.
  • Initial surgery improved symptoms, but a residual mass enlarged, causing visual impairment.
  • High-dose methylprednisolone therapy led to significant mass reduction and symptom improvement.

Conclusions:

  • This case supports an autoimmune etiology for xanthomatous hypophysitis.
  • High-dose glucocorticoid therapy is a viable treatment option for residual or recurrent xanthomatous hypophysitis.
  • Multidisciplinary management involving surgery and immunotherapy may be beneficial.