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Updated: May 4, 2026

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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
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The effect of a macrocyclic constraint on electron transfer in helical peptides: a step towards tunable molecular
Jingxian Yu1, John R Horsley, Katherine E Moore
1School of Chemistry and Physics, The University of Adelaide, Adelaide, SA 5005, Australia. jingxian.yu@adelaide.edu.au andrew.abell@adelaide.edu.au.
Abstract:
Two helical peptides, one constrained by a covalent side-chain staple, exhibit vastly different electronic properties despite adopting essentially the same backbone conformation. High level calculations confirm that these differences are due to the additional backbone rigidity imparted by the macrocyclic constraint.

