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Single molecule ionic current sensing in segmented flow microfluidics.

Thomas R Gibb1, Aleksandar P Ivanov, Joshua B Edel

  • 1Department of Chemistry, Imperial College London , South Kensington Campus, London, SW7 2AZ, United Kingdom.

Analytical Chemistry
|January 9, 2014
PubMed
Summary
This summary is machine-generated.

This study integrates glass nanopores into microfluidic devices for label-free, single-molecule sensing. It combines droplet microfluidics with nanopore detection for enhanced sensitivity and molecular-level control.

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Area of Science:

  • Analytical Chemistry
  • Biotechnology
  • Microfluidics

Background:

  • Label-free, single-molecule detection is crucial for understanding complex biological systems.
  • Droplet microfluidics offers isolated microreactors for precise control over reactions.
  • Nanopore sensing provides high sensitivity for analyzing individual molecules.

Purpose of the Study:

  • To enhance label-free, single-molecule nanopore sensor functionality.
  • To integrate glass nanopores into a segmented flow microfluidic device.
  • To combine droplet microfluidics with nanopore sensing for improved analytical capabilities.

Main Methods:

  • Integration of two glass nanopores into a microfluidic device.
  • Utilizing segmented flow for droplet microfluidics.
  • Electrochemical detection of single-molecule translocations via the Coulter principle.

Main Results:

  • Successful integration of glass nanopores within a microfluidic platform.
  • Distinguishing individual droplet compositions.
  • Detecting single-molecule translocations electrochemically with high sensitivity.
  • Demonstrating the "isolated microreactor" benefits of droplet microfluidics.

Conclusions:

  • The developed device enhances single-molecule nanopore sensor functionality.
  • This approach combines the sensitivity of single-molecule methods with droplet microfluidics.
  • The platform enables molecular-level control over droplet composition through controlled injection and extraction.