Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

2.0K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
2.0K
Interference and Decay01:16

Interference and Decay

609
Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
609
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

926
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
926
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.2K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.2K
Long-term Potentiation01:25

Long-term Potentiation

2.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
2.7K
Long-term Potentiation01:35

Long-term Potentiation

51.6K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
51.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aphantasia is associated with spatial memory and navigation difficulties in complex virtual environments.

Neuropsychologia·2026
Same author

Separable cognitive and motor decline tracked across adult life-span for goal-directed navigation.

iScience·2025
Same author

Brain Dynamics during Architectural Experience: Prefrontal and Hippocampal Regions Track Aesthetics and Spatial Complexity.

Journal of cognitive neuroscience·2025
Same author

Education Is Positively and Causally Linked With Spatial Navigation Ability Across the Lifespan.

Open mind : discoveries in cognitive science·2025
Same author

Awake replay: off the clock but on the job.

Trends in neurosciences·2025
Same author

Replaying off the beaten path.

Science (New York, N.Y.)·2025

Related Experiment Video

Updated: May 4, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
09:39

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

26.7K

Enhance, delete, incept: manipulating hippocampus-dependent memories.

Hugo J Spiers1, Daniel Bendor1

  • 1Institute of Behavioural Neuroscience, Research Department of Cognitive, Perceptual and Brain Sciences, Division of Psychology and Language Sciences, University College London, 26 Bedford Way, London WC1H 0AP, UK.

Brain Research Bulletin
|January 9, 2014
PubMed
Summary

Recent memory manipulation research explores hippocampal memory modification. Techniques like optogenetics and brain stimulation are advancing our understanding of memory enhancement.

Keywords:
ExtinctionFear conditioningHippocampusMemory consolidationReconsolidationSleep

More Related Videos

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

15.6K
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

14.9K

Related Experiment Videos

Last Updated: May 4, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
09:39

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

26.7K
Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

15.6K
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

14.9K

Area of Science:

  • Neuroscience
  • Cognitive Science

Background:

  • The hippocampus is crucial for memory formation and retrieval.
  • Understanding memory manipulation is key to advancing cognitive science.

Purpose of the Study:

  • To provide an overview of recent research in memory manipulation.
  • To highlight the expanding repertoire of methods used to study memory.

Main Methods:

  • Optogenetics
  • Transcranial stimulation
  • Deep brain stimulation
  • Cued reactivation during sleep
  • Pharmacological agents
  • Single unit recording
  • Functional magnetic resonance imaging (fMRI)

Main Results:

  • The study reviews various techniques for memory manipulation.
  • Investigates the underlying mechanisms of memory changes.
  • Focuses on hippocampus-dependent memories.

Conclusions:

  • The field of memory manipulation is rapidly evolving.
  • Diverse methods are available for studying and potentially enhancing memory.
  • Further research is needed to fully understand memory mechanisms.