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Updated: May 4, 2026

Immunohistochemical Staining of B7-H1 PD-L1 on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue
Published on: January 3, 2013
The immunoinhibitory B7-H1 molecule as a potential target in cancer: killing many birds with one stone
1Immunology and Innovative Cell Therapy Unit, Biomedical Research Facility, Research Center, King Fahad Specialist Hospital Dammam, PO Box 15215, 31444 Dammam, Saudi Arabia.
Abstract:
Over expression of B7-H1 (also named PDL-1 or CD 274) molecule in cancer has been linked to worse prognosis and resistance to anti-cancer therapies in several malignancies. In this review, we update on the expression of B7-H1 molecule in solid and hematological malignancies. We also describe the possible mechanisms by which this molecule inhibits/downregulates the immune response to cancer cells. Finally, we highlight current and future potential therapeutic strategies that can be further developed to target this molecule.
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